Our understanding of how DNA copy number changes contribute to disease, including cancer, has to a large degree been focused on the changes in gene dosage that they generate and has neglected the effects of the DNA rearrangements that lead to their formation. A new study reports an innovative analytical framework for copy number alterations that are oncogenic primarily owing to the genomic rearrangements that underlie them.
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References
Zack, T.I. et al. Nat. Genet. 45, 1134–1140 (2013).
Weischenfeldt, J. et al. Nat. Genet. 49, 65–74 (2017).
Wong, A.J. et al. Proc. Natl. Acad. Sci. USA 89, 2965–2969 (1992).
Ong, C.-T. & Corces, V.G. Nat. Rev. Genet. 12, 283–293 (2011).
Hnisz, D., Day, D.S. & Young, R.A. Cell 167, 1188–1200 (2016).
Northcott, P.A. et al. Nature 511, 428–434 (2014).
Battey, J. et al. Cell 34, 779–787 (1983).
Bandopadhayay, P. et al. Nat. Genet. 48, 273–282 (2016).
Tomlins, S.A. et al. Science 310, 644–648 (2005).
Gröschel, S. et al. Cell 157, 369–381 (2014).
Zhang, X. et al. Nat. Genet. 48, 176–182 (2016).
Hnisz, D. et al. Science 351, 1454–1458 (2016).
Cancer Genome Atlas Network. Nature 487, 330–337 (2012).
Stephens, P.J. et al. Cell 144, 27–40 (2011).
Baca, S.C. et al. Cell 153, 666–677 (2013).
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R.B. receives research support from and is a consultant for Novartis. M.M. receives research support from Bayer and is a founding advisor of Foundation Medicine, for which he was previously a consultant and in which he previously held equity.
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Beroukhim, R., Zhang, X. & Meyerson, M. Copy number alterations unmasked as enhancer hijackers. Nat Genet 49, 5–6 (2017). https://doi.org/10.1038/ng.3754
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DOI: https://doi.org/10.1038/ng.3754
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