Supplementary Figure 14: 6AN selectively blocked 3D tumor formation in distant metastatic subclones. | Nature Genetics

Supplementary Figure 14: 6AN selectively blocked 3D tumor formation in distant metastatic subclones.

From: Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

Supplementary Figure 14

(a,b) 6AN did not interfere with the ability of regional PDAC samples to form tumors in 3D Matrigel assays (a) or in 3D suspension tumorsphere assays (b). n = 2–4 technical replicates; error bars, s.d. (c) In contrast, 6AN strongly blocked the ability of distant metastatic subclones to form tumors in 3D suspension tumorsphere assays. n = 4 technical replicates; error bars, s.d. *P < 0.003, two-tailed t test. Scale bars, 400 μm.

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