Supplementary Figure 12: 6AN selectively modulated the reprogrammed chromatin state of distant metastatic subclones. | Nature Genetics

Supplementary Figure 12: 6AN selectively modulated the reprogrammed chromatin state of distant metastatic subclones.

From: Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

Supplementary Figure 12

(a) 6AN treatments generally increased global H3K9me2 with corresponding decreased acetylation in distant metastatic subclones. (b) Normal cells and local regional PDACs did not show such changes. (c) 6AN changes persisted after 3 d of treatment (+) followed by removal of 6AN from the medium (+–) for an additional 3 d.

Back to article page