Supplementary Figure 11: 6AN targets glucose metabolism and the PGD step of the oxPPP. | Nature Genetics

Supplementary Figure 11: 6AN targets glucose metabolism and the PGD step of the oxPPP.

From: Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

Supplementary Figure 11

(a) 6AN selectively slowed rates of extracellular glucose consumption and lactate secretion in precursor (A13Pr1) and metastatic (A13Lg, A38Lg) subclones, with no effect on glutamine or glutamate. (b) 6AN reduced incorporation of intracellular 13C-labeled glucose into metabolites downstream of the oxPPP. (c) 6AN greatly increased levels of the PGD substrate (6PG) and upstream metabolites with corresponding reductions in the levels of downstream products. (d) Scatterplots with correlation coefficients confirmed that 6AN gene expression changes were targeted to DE genes detected in A38Per (versus A38Lg) and that this was a partial, quantitative effect.

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