Supplementary Figure 10: Enhanced glucose metabolism with depleted 6PG across distant metastatic and precursor subclones. | Nature Genetics

Supplementary Figure 10: Enhanced glucose metabolism with depleted 6PG across distant metastatic and precursor subclones.

From: Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

Supplementary Figure 10

(a) Extracellular glucose consumption and lactate secretion were elevated in A38Lg, A13Pr1, and A13Lg relative to A38Per. (b) Schematic of glycolytic (outside) and PPP (boxed) metabolites, with intracellular metabolite levels detected by LC–HRMS plotted for each sample. Data represent LC–HRMS signals normalized to total protein for each sample, as indicated on the y axis.

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