Supplementary Figure 7: Reprogramming of large LOCK domains during PDAC evolution. | Nature Genetics

Supplementary Figure 7: Reprogramming of large LOCK domains during PDAC evolution.

From: Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

Supplementary Figure 7

(ac) H3K9me3 was enriched and DNA was hypomethylated within large LOCK domains. (b,c) Striking reciprocal reprogramming of H3K9me2 and H3K9me3 and DNA methylation was detected in a subset of large LOCKs in patient A38. (d) H3K9me3 was enriched across large HPDE LOCKs. (e) Examples of reprogrammed domains between samples across a 25-Mb locus on chromosome 13.

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