Supplementary Figure 6: Specificity of chromatin modifications within ECDs. | Nature Genetics

Supplementary Figure 6: Specificity of chromatin modifications within ECDs.

From: Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

Supplementary Figure 6

(a) Plots of ChIP–seq read densities normalized to input for histone modifications (left labels) showed that euchromatin modifications (H3K36me3, H3K27ac; H3K4me3 is not shown) were enriched in regions that were called ECDs (0% to 100%; bottom labels) for each subclone (indicated above). In contrast, heterochromatin modifications (H3K9me2, H3K9me3, H3K27me3) were depleted from ECDs. (b) Euchromatin domains detected using alternative thresholds for domain calls (removal of short peaks less than 10 kb in length and merging of broad peaks separated by 15 kb) produced similar results as shown in Figure 2d, demonstrating that the domain calls were robust across multiple criteria. The y axes represent ChIP–seq read densities normalized to input for both panels.

Back to article page