Supplementary Figure 5: Localized reprogramming of DE gene loci within LOCK domains. | Nature Genetics

Supplementary Figure 5: Localized reprogramming of DE gene loci within LOCK domains.

From: Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

Supplementary Figure 5

(a) Mapping DE genes from RNA–seq (distant metastases and precursors versus A38Per) to LOCKs revealed reciprocal changes in H3K27me3 and H3K27ac + H3K36me3 + DNA methylation around genes downregulated in LOCKs. (b) The opposite changes in H3K27me3 and H3K27ac + H3K36me3 were detected from genes upregulated in LOCKs. DNA methylation remained high in these regions.

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