Supplementary Figure 4: Reprogramming of H3K9me3 in LOCKs during PDAC subclonal evolution. | Nature Genetics

Supplementary Figure 4: Reprogramming of H3K9me3 in LOCKs during PDAC subclonal evolution.

From: Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

Supplementary Figure 4

(a) ChIP–seq data from paired peritoneal (A38Per) and lung (A38Lg) metastatic subclones detected dramatic reduction of H3K9me3 in A38Lg that overlapped with H3K9me2 in LOCK domains. (b) Similar data were found for patient A13, which also showed loss of H3K9me3 from LOCK regions in the A13Pr2 and A13Lg subclones, as compared to the A13Pr1 primary tumor subclone.

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