Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Understanding unspecific complaints through genetics

Unspecific and unexplained medical complaints can be frustrating to both patients and clinicians. A cause for these complex symptoms and signs may now have been identified.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. Lyons, J.J. et al. Nat. Genet. 48, 1564–1569 (2016).

    Article  CAS  Google Scholar 

  2. Eikelboom, E.M., Tak, L.M., Roest, A.M. & Rosmalen, J.G. J. Psychosom. Res. 88, 60–67 (2016).

    Article  CAS  Google Scholar 

  3. Lyons, J.J. et al. J. Allergy Clin. Immunol. 133, 1471–1474 (2014).

    Article  CAS  Google Scholar 

  4. Beyder, A. & Farrugia, G. Am. J. Physiol. Gastrointest. Liver Physiol. 311, G581–G586 (2016).

    Article  Google Scholar 

  5. Cordero, M.D. et al. J. Med. Genet. 53, 113–122 (2016).

    Article  CAS  Google Scholar 

  6. Petra, A.I., Panagiotidou, S., Stewart, J.M., Conti, P. & Theoharides, T.C. Expert Rev. Clin. Immunol. 10, 729–739 (2014).

    Article  CAS  Google Scholar 

  7. Kumar, S., Ranjan, P., Mittal, B. & Ghoshal, U.C. J. Gastrointestin. Liver Dis. 21, 31–38 (2012).

    PubMed  Google Scholar 

  8. Kapeller, J. et al. Hum. Mol. Genet. 17, 2967–2977 (2008).

    Article  CAS  Google Scholar 

  9. Feng, J. et al. PLoS One 8, e65033 (2013).

    Article  CAS  Google Scholar 

  10. Vitte, J. Mol. Immunol. 63, 18–24 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Eli Sprecher.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Sprecher, E. Understanding unspecific complaints through genetics. Nat Genet 48, 1450–1451 (2016). https://doi.org/10.1038/ng.3730

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.3730

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing