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The gut microbiome—an emerging complex trait

As the first series of genetic analyses of gut microbiome composition in humans is now emerging, the results should be met with enthusiasm, but also with caution. Findings from the initial offerings demonstrate how population-scale approaches can provide deeper insights into host–microbiome interactions while at the same time illustrating that our understanding of the architecture of highly complex microbiome 'traits' is still rudimentary.

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Figure 1: The spectrum of quantitative features of the microbiome giving rise to significant trait associations.


  1. Benson, A.K. et al. Proc. Natl. Acad. Sci. USA 107, 18933–18938 (2010).

    Article  CAS  Google Scholar 

  2. Org, E. et al. Genome Res. 25, 1558–1569 (2015).

    Article  CAS  Google Scholar 

  3. McKnite, A.M. et al. PLoS One 7, e39191 (2012).

    Article  CAS  Google Scholar 

  4. Srinivas, G. et al. Nat. Commun. 4, 2462 (2013).

    Article  Google Scholar 

  5. Leamy, L.J. et al. Genome Biol. 15, 552 (2014).

    Article  Google Scholar 

  6. Blekhman, R. et al. Genome Biol. 16, 191 (2015).

    Article  Google Scholar 

  7. Goodrich, J.K. et al. Cell 159, 789–799 (2014).

    Article  CAS  Google Scholar 

  8. Goodrich, J.K. et al. Cell Host Microbe 19, 731–743 (2016).

    Article  CAS  Google Scholar 

  9. Turpin, W. et al. Nat. Genet. 48, 1413–1417 (2016).

    Article  CAS  Google Scholar 

  10. Bonder, M.J. et al. Nat. Genet. 48, 1407–1412 (2016).

    Article  CAS  Google Scholar 

  11. Wang, J. et al. Nat. Genet. 48, 1396–1406 (2016).

    Article  CAS  Google Scholar 

  12. Eichler, E.E. et al. Nat. Rev. Genet. 11, 446–450 (2010).

    Article  CAS  Google Scholar 

  13. Costello, E.K., Stagaman, K., Dethlefsen, L., Bohannan, B.J.M. & Relman, D.A. Science 336, 1255–1262 (2012).

    Article  CAS  Google Scholar 

  14. Visscher, P.M. Genetics 202, 377–379 (2016).

    Article  CAS  Google Scholar 

  15. Visscher, P.M. & Yang, J. Nat. Genet. 48, 707–708 (2016).

    Article  CAS  Google Scholar 

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Correspondence to Andrew K Benson.

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Benson, A. The gut microbiome—an emerging complex trait. Nat Genet 48, 1301–1302 (2016).

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