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p53 partners with RNA in the DNA damage response

Stabilization of p53 protein is a key step in the cellular response to DNA damage. A new study describes a long noncoding RNA, DINO, transcribed from the CDKN1A promoter region that induces stabilization of p53 protein and promotes efficient activation of p53 target genes in response to DNA damage.

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Figure 1: Model of DINO function.


  1. Menendez, D., Inga, A. & Resnick, M.A. Nat. Rev. Cancer 9, 724–737 (2009).

    Article  CAS  Google Scholar 

  2. Grossi, E., Sánchez, Y. & Huarte, M. Biochim. Biophys. Acta 1859, 200–208 (2016).

    Article  CAS  Google Scholar 

  3. Djebali, S. et al. Nature 489, 101–108 (2012).

    Article  CAS  Google Scholar 

  4. Guttman, M. et al. Nature 458, 223–227 (2009).

    Article  CAS  Google Scholar 

  5. Schmitt, A.M. et al. Nat. Genet. 48, 1370–1376 (2016).

    Article  CAS  Google Scholar 

  6. Ulitsky, I. Nat. Rev. Genet. 17, 601–614 (2016).

    Article  CAS  Google Scholar 

  7. Ulitsky, I. & Bartel, D.P. Cell 154, 26–46 (2013).

    Article  CAS  Google Scholar 

  8. Brown, J.P., Wei, W. & Sedivy, J.M. Science 277, 831–834 (1997).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Maite Huarte.

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Huarte, M. p53 partners with RNA in the DNA damage response. Nat Genet 48, 1298–1299 (2016).

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