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CREBRF variant increases obesity risk and protects against diabetes in Samoans

Nature Genetics volume 48, pages 976978 (2016) | Download Citation

A genome-wide study in Samoans has identified a protein-altering variant (p.Arg475Gln) in CREBRF as being associated with 1.3-fold increased risk of obesity and, intriguingly, 1.6-fold decreased risk of type 2 diabetes. This variant, which is common among Samoans (minor allele frequency = 26%) but extremely rare in other populations, promotes fat storage and reduces energy use in cellular models.

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Author information

Affiliations

  1. Ruth J.F. Loos is at the Charles Bronfman Institute for Personalized Medicine, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

    • Ruth J F Loos

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Ruth J F Loos.

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DOI

https://doi.org/10.1038/ng.3653

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