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Genomic landscape of the Greater Middle East

Study of the Greater Middle East (GME), home to approximately 10% of the world's population, has made invaluable contributions to the characterization of rare genetic disease, especially recessive conditions arising from the tradition of consanguinity and large families with multiple children. A new study now reports 1,111 unrelated exomes from the GME and provides a comprehensive view of genetic variation for enhanced discovery of disease-associated genes.

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Figure 1: Reverse phenotyping of complex diseases.


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Correspondence to Tayfun Özçelik.

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Özçelik, T., Onat, O. Genomic landscape of the Greater Middle East. Nat Genet 48, 978–979 (2016).

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