A new analysis has characterized a fundamental building block of complex transcribed loci. Constellations of core promoters can generally be reduced to pairs of divergent transcription units, where the distance between the pairs of transcription units correlates with constraints on genomic context, which in turn contribute to transcript fate.
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Kaplan, C. Pairs of promoter pairs in a web of transcription. Nat Genet 48, 975–976 (2016). https://doi.org/10.1038/ng.3649
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DOI: https://doi.org/10.1038/ng.3649
