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DNA-sequence-specific erasers of epigenetic memory

How epigenetic regulators find their specific targets remains a challenging question. Two parallel studies show that REF6, a plant H3K27me3 demethylase, binds a specific DNA motif via its zinc-finger domains and recruits the SWI/SNF-type ATPase BRAHMA, demonstrating a sequence-specific recruitment mechanism for a chromatin-modifying complex.

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Figure 1: Mechanism of REF6 recruitment and function.

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Correspondence to Claudia Köhler.

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Mozgova, I., Köhler, C. DNA-sequence-specific erasers of epigenetic memory. Nat Genet 48, 591–592 (2016). https://doi.org/10.1038/ng.3579

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