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DNA-sequence-specific erasers of epigenetic memory

Nature Genetics volume 48, pages 591–592 (2016)Cite this article

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How epigenetic regulators find their specific targets remains a challenging question. Two parallel studies show that REF6, a plant H3K27me3 demethylase, binds a specific DNA motif via its zinc-finger domains and recruits the SWI/SNF-type ATPase BRAHMA, demonstrating a sequence-specific recruitment mechanism for a chromatin-modifying complex.

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Figure 1: Mechanism of REF6 recruitment and function.

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Authors and Affiliations

  1. Iva Mozgova and Claudia Köhler are in the Department of Plant Biology, Uppsala BioCenter, Swedish University of Agricultural Sciences and the Linnean Center for Plant Biology, Uppsala, Sweden.,

    Iva Mozgova & Claudia Köhler

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  1. Iva Mozgova
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  2. Claudia Köhler
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Correspondence to Claudia Köhler.

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The authors declare no competing financial interests.

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Mozgova, I., Köhler, C. DNA-sequence-specific erasers of epigenetic memory. Nat Genet 48, 591–592 (2016). https://doi.org/10.1038/ng.3579

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