A new mouse model linking diabetes, insulin secretion and autoimmunity with a high-fat diet supports a shared mechanism for type 1 (T1D) and type 2 (T2D) diabetes. In this model, the protein secretion system of insulin-producing pancreatic beta cells is stressed, leading to increased beta cell apoptosis and diabetes via reduced levels of the transcription factor GLIS3, a pathogenic pathway that can be mimicked by a high-fat diet.
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Todd, J. Intolerable secretion and diabetes in tolerant transgenic mice, revisited. Nat Genet 48, 476–477 (2016). https://doi.org/10.1038/ng.3560
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DOI: https://doi.org/10.1038/ng.3560
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