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Connecting the regulatory genome

Determining how the evolving genome-wide map of distal regulatory elements is connected with target genes has remained a significant challenge, despite progress in understanding chromatin architecture and regulation. A new study presents a computational approach for predicting distal element–gene interactions.

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Figure 1: Connecting distal elements with target genes.


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Correspondence to John Stamatoyannopoulos.

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Stamatoyannopoulos, J. Connecting the regulatory genome. Nat Genet 48, 479–480 (2016).

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