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Tet proteins enhance the developmental hourglass

A new study compares DNA methylation profiles in developing zebrafish, Xenopus tropicalis and mice and suggests roles for Tet proteins in demethylating conserved gene enhancers during the phylotypic period of early development. These findings provide an epigenetic underpinning for the 'hourglass' model.

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Figure 1: Depiction of the hourglass model of early development and its molecular underpinning.


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Correspondence to Bradley R Cairns.

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Hendrickson, P., Cairns, B. Tet proteins enhance the developmental hourglass. Nat Genet 48, 345–347 (2016).

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