Current efforts in cellular disease modeling and regenerative medicine are limited by the paucity of cell types that can be generated in the laboratory. A new study introduces a computational framework, Mogrify, that uses network biology to predict combinations of transcription factors necessary for direct conversion between human cell types to ameliorate this issue.
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The author declares no competing financial interests.
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Cahan, P. Enabling direct fate conversion with network biology. Nat Genet 48, 226–227 (2016). https://doi.org/10.1038/ng.3516