Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Biodiversity and hypervirulence of Listeria monocytogenes

The integration of large, well-sampled collections of bacterial isolates with genomics and experimental methods provides opportunities for 'top-down' discovery of the genetic basis of phenotypes of interest. In a new report, the authors apply this approach to investigate the heterogeneity in manifestations of disease caused by Listeria monocytogenes and demonstrate that a previously uncharacterized cellobiose PTS system is involved in central nervous system infection.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A pregnant woman eating an ice cream cone contaminated with L. monocytogenes, which are depicted as brown flagellated bacteria in the zoom-in callout.

Marina Corral Spence/Nature Publishing Group


  1. Maury, M.M. et al. Nat. Genet. 48, 308–313 (2016).

    Article  CAS  Google Scholar 

  2. Scallan, E. et al. Emerg. Infect. Dis. 17, 7–15 (2011).

    Article  Google Scholar 

  3. Hohmann, E.L. & Portnoy, D.A. in Harrison's Principles of Internal Medicine 18th edn (eds. Longo, D.L. et al.) Ch. 139, 1194–1196 (McGraw Hill Professional, 2011).

    Google Scholar 

  4. Gahan, C.G. & Hill, C. Front. Cell. Infect. Microbiol. 4, 9 (2014).

    Article  Google Scholar 

  5. Esteban, J.I., Oporto, B., Aduriz, G., Juste, R.A. & Hurtado, A. BMC Vet. Res. 5, 2 (2009).

    Article  Google Scholar 

  6. Vázquez-Boland, J.A. et al. Clin. Microbiol. Rev. 14, 584–640 (2001).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Yonatan H Grad or Sarah M Fortune.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Grad, Y., Fortune, S. Biodiversity and hypervirulence of Listeria monocytogenes. Nat Genet 48, 229–230 (2016).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing Microbiology

Sign up for the Nature Briefing: Microbiology newsletter — what matters in microbiology research, free to your inbox weekly.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing: Microbiology