The integration of large, well-sampled collections of bacterial isolates with genomics and experimental methods provides opportunities for 'top-down' discovery of the genetic basis of phenotypes of interest. In a new report, the authors apply this approach to investigate the heterogeneity in manifestations of disease caused by Listeria monocytogenes and demonstrate that a previously uncharacterized cellobiose PTS system is involved in central nervous system infection.
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Grad, Y., Fortune, S. Biodiversity and hypervirulence of Listeria monocytogenes. Nat Genet 48, 229–230 (2016). https://doi.org/10.1038/ng.3515
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DOI: https://doi.org/10.1038/ng.3515
