Iron is essential in multiple cellular processes and is especially critical for cellular respiration and division. A new study identified a mutation affecting the iron import receptor TfR1 as the cause of a human primary immunodeficiency, illuminating the importance of iron in immune cell function.
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References
Jabara, H.H. et al. Nat. Genet. 48, 74–78 (2016).
Picard, C. et al. J. Clin. Immunol. 35, 696–726 (2015).
Andrews, N.C. Nat. Rev. Genet. 1, 208–217 (2000).
Kühn, L.C. Metallomics 7, 232–243 (2015).
Cassat, J.E. & Skaar, E.P. Cell Host Microbe 13, 509–519 (2013).
He, M., Cortizas, E.M., Verdun, R.E. & Severinson, E. J. Immunol. 194, 4231–4239 (2015).
Levy, J.E., Jin, O., Fujiwara, Y., Kuo, F. & Andrews, N.C. Nat. Genet. 21, 396–399 (1999).
Ohgami, R.S. et al. Nat. Genet. 37, 1264–1269 (2005).
Ohgami, R.S., Campagna, D.R., McDonald, A. & Fleming, M.D. Blood 108, 1388–1394 (2006).
Sargent, P.J., Farnaud, S. & Evans, R.W. Curr. Med. Chem. 12, 2683–2693 (2005).
Bowlus, C.L. Autoimmun. Rev. 2, 73–78 (2003).
Kuvibidila, S., Dardenne, M., Savino, W. & Lepault, F. Am. J. Clin. Nutr. 51, 228–232 (1990).
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Lo, B. The requirement of iron transport for lymphocyte function. Nat Genet 48, 10–11 (2016). https://doi.org/10.1038/ng.3478
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DOI: https://doi.org/10.1038/ng.3478