Large sample sizes, high-resolution arrays and comprehensive imputation are pushing genetic fine-mapping of complex trait loci to its limits without, in most cases, pinpointing a unique variant-gene combination. Superimposing these results on sophisticated maps of functional chromatin elements promises to break this logjam, as a new study of type 2 diabetes compellingly demonstrates.
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Polychronakos, C., Alriyami, M. Diabetes in the post-GWAS era. Nat Genet 47, 1373–1374 (2015). https://doi.org/10.1038/ng.3453
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DOI: https://doi.org/10.1038/ng.3453
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