Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Diabetes in the post-GWAS era

Large sample sizes, high-resolution arrays and comprehensive imputation are pushing genetic fine-mapping of complex trait loci to its limits without, in most cases, pinpointing a unique variant-gene combination. Superimposing these results on sophisticated maps of functional chromatin elements promises to break this logjam, as a new study of type 2 diabetes compellingly demonstrates.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Proposed mechanism for the contribution of variation in MTNR1B to type 2 diabetes risk.

Katie Vicari/Nature Publishing Group


  1. Wall, J.D. & Pritchard, J.K. Nat. Rev. Genet. 4, 587–597 (2003).

    Article  CAS  Google Scholar 

  2. Gaulton, K.J. et al. Nat. Genet. 47, 1415–1425 (2015).

    Article  CAS  Google Scholar 

  3. Voight, B.F. et al. PLoS Genet. 8, e1002793 (2012).

    Article  CAS  Google Scholar 

  4. ENCODE Project Consortium. Nature 489, 57–74 (2012).

  5. Trynka, G. et al. Nat. Genet. 45, 124–130 (2013).

    Article  CAS  Google Scholar 

  6. Parker, S.C. et al. Proc. Natl. Acad. Sci. USA 110, 17921–17926 (2013).

    Article  CAS  Google Scholar 

  7. Okada, Y. et al. Nature 506, 376–381 (2014).

    Article  CAS  Google Scholar 

  8. Farh, K.K. et al. Nature 518, 337–343 (2015).

    Article  CAS  Google Scholar 

  9. Onengut-Gumuscu, S. et al. Nat. Genet. 47, 381–386 (2015).

    Article  CAS  Google Scholar 

  10. Pasquali, L. et al. Nat. Genet. 46, 136–143 (2014).

    Article  CAS  Google Scholar 

  11. Lantz, K.A. et al. J. Clin. Invest. 114, 512–520 (2004).

    Article  CAS  Google Scholar 

  12. Lee, C.S. et al. Diabetes 51, 2546–2551 (2002).

    Article  CAS  Google Scholar 

  13. Mohlke, K.L. & Boehnke, M. Hum. Mol. Genet. 24, R85–R92 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Constantin Polychronakos.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Polychronakos, C., Alriyami, M. Diabetes in the post-GWAS era. Nat Genet 47, 1373–1374 (2015).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing