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Small island, big genetic discoveries

Nature Genetics volume 47, pages 12241225 (2015) | Download Citation

Three new studies have identified new genes and sequence variants implicated in blood lipids, inflammatory markers, hemoglobin levels and adult height variation in Sardinia. These reports highlight the usefulness of large-scale genotype imputation based on whole-genome sequencing, particularly in isolated populations, in studying the genetics of complex human phenotypes.

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Author information

Affiliations

  1. Guillaume Lettre is at the Montreal Heart Institute, Montreal, Quebec, Canada, and the Faculté de Médecine, Université de Montréal, Montreal, Quebec, Canada.

    • Guillaume Lettre
  2. Joel N. Hirschhorn is at the Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA, the Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA, and the Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.

    • Joel N Hirschhorn

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Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Guillaume Lettre or Joel N Hirschhorn.

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DOI

https://doi.org/10.1038/ng.3426

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