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PRC1 proteins orchestrate three-dimensional genome architecture

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The three-dimensional organization of the genome has an important role in orchestrating gene expression, but its regulation is poorly understood. Now, a new study uncovers a major role for Polycomb components of the PRC1 complex in organizing physical networks of genes that are co-repressed to maintain pluripotency.

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Figure 1: Wiring of the Polycomb network during the maintenance of pluripotency and during cell differentiation.

Katie Vicari/Nature Publishing Group

References

  1. Lieberman-Aiden, E. et al. Science 326, 289–293 (2009).

    Article  CAS  Google Scholar 

  2. Mifsud, B. et al. Nat. Genet. 47, 598–606 (2015).

    Article  CAS  Google Scholar 

  3. Sexton, T. & Cavalli, G. Cell 160, 1049–1059 (2015).

    Article  CAS  Google Scholar 

  4. Festuccia, N., Osorno, R., Wilson, V. & Chambers, I. Curr. Opin. Genet. Dev. 23, 504–511 (2013).

    Article  CAS  Google Scholar 

  5. Simon, J.A. & Kingston, R.E. Mol. Cell 49, 808–824 (2013).

    Article  CAS  Google Scholar 

  6. Bantignies, F. et al. Cell 144, 214–226 (2011).

    Article  CAS  Google Scholar 

  7. Sexton, T. et al. Cell 148, 458–472 (2012).

    Article  CAS  Google Scholar 

  8. Denholtz, M. et al. Cell Stem Cell 13, 602–616 (2013).

    Article  CAS  Google Scholar 

  9. Vieux-Rochas, M., Fabre, P.J., Leleu, M., Duboule, D. & Noordermeer, D. Proc. Natl. Acad. Sci. USA 112, 4672–4677 (2015).

    Article  CAS  Google Scholar 

  10. Schoenfelder, S. et al. Nat. Genet. 47, 1179–1186 (2015).

    Article  CAS  Google Scholar 

  11. de Wit, E. et al. Nature 501, 227–231 (2013).

    Article  CAS  Google Scholar 

  12. Rosa, S. et al. Genes Dev. 27, 1845–1850 (2013).

    Article  CAS  Google Scholar 

  13. Isono, K. et al. Dev. Cell 26, 565–577 (2013).

    Article  CAS  Google Scholar 

  14. Vidal, M. Int. J. Dev. Biol. 53, 355–370 (2009).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Giacomo Cavalli.

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Cavalli, G. PRC1 proteins orchestrate three-dimensional genome architecture. Nat Genet 47, 1105–1106 (2015). https://doi.org/10.1038/ng.3411

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