The three-dimensional organization of the genome has an important role in orchestrating gene expression, but its regulation is poorly understood. Now, a new study uncovers a major role for Polycomb components of the PRC1 complex in organizing physical networks of genes that are co-repressed to maintain pluripotency.
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References
Lieberman-Aiden, E. et al. Science 326, 289–293 (2009).
Mifsud, B. et al. Nat. Genet. 47, 598–606 (2015).
Sexton, T. & Cavalli, G. Cell 160, 1049–1059 (2015).
Festuccia, N., Osorno, R., Wilson, V. & Chambers, I. Curr. Opin. Genet. Dev. 23, 504–511 (2013).
Simon, J.A. & Kingston, R.E. Mol. Cell 49, 808–824 (2013).
Bantignies, F. et al. Cell 144, 214–226 (2011).
Sexton, T. et al. Cell 148, 458–472 (2012).
Denholtz, M. et al. Cell Stem Cell 13, 602–616 (2013).
Vieux-Rochas, M., Fabre, P.J., Leleu, M., Duboule, D. & Noordermeer, D. Proc. Natl. Acad. Sci. USA 112, 4672–4677 (2015).
Schoenfelder, S. et al. Nat. Genet. 47, 1179–1186 (2015).
de Wit, E. et al. Nature 501, 227–231 (2013).
Rosa, S. et al. Genes Dev. 27, 1845–1850 (2013).
Isono, K. et al. Dev. Cell 26, 565–577 (2013).
Vidal, M. Int. J. Dev. Biol. 53, 355–370 (2009).
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Cavalli, G. PRC1 proteins orchestrate three-dimensional genome architecture. Nat Genet 47, 1105–1106 (2015). https://doi.org/10.1038/ng.3411
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DOI: https://doi.org/10.1038/ng.3411
