The three-dimensional organization of the genome has an important role in orchestrating gene expression, but its regulation is poorly understood. Now, a new study uncovers a major role for Polycomb components of the PRC1 complex in organizing physical networks of genes that are co-repressed to maintain pluripotency.
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Cavalli, G. PRC1 proteins orchestrate three-dimensional genome architecture. Nat Genet 47, 1105–1106 (2015). https://doi.org/10.1038/ng.3411