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Linking germline and somatic variation in Ewing sarcoma

Nature Genetics volume 47, pages 964965 (2015) | Download Citation

The identification of gene-regulatory polymorphisms that influence cancer susceptibility can identify key oncogenic pathways. A new study links a germline variant to Ewing sarcoma disease susceptibility and EWSR1-FLI1–mediated gene activation.

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Author information

Affiliations

  1. Nicholas C. Gomez and Ian J. Davis are in the Department of Genetics and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

    • Nicholas C Gomez
    •  & Ian J Davis

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Ian J Davis.

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DOI

https://doi.org/10.1038/ng.3387

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