The identification of gene-regulatory polymorphisms that influence cancer susceptibility can identify key oncogenic pathways. A new study links a germline variant to Ewing sarcoma disease susceptibility and EWSR1-FLI1–mediated gene activation.
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Gomez, N., Davis, I. Linking germline and somatic variation in Ewing sarcoma. Nat Genet 47, 964–965 (2015). https://doi.org/10.1038/ng.3387
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DOI: https://doi.org/10.1038/ng.3387
