Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Building a staircase to precision medicine for biliary tract cancer

A new study has conducted a comprehensive exome and transcriptome analysis of a large number of intrahepatic, perihilar and distal cholangiocarcinomas and gallbladder cancers in Japanese patients. This study identifies many new alterations, confirms genetic differences in these distinct subtypes of biliary tract cancer and demonstrates that approximately 40% of described genetic aberrations are potentially targetable.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1

Marina Corral Spence/Nature Publishing Group


  1. Razumilava, N. & Gores, G.J. Lancet 383, 2168–2179 (2014).

    Article  Google Scholar 

  2. Sia, D. et al. Gastroenterology 144, 829–840 (2013).

    Article  CAS  Google Scholar 

  3. Homayounfar, K. et al. Hum. Pathol. 40, 834–842 (2009).

    Article  CAS  Google Scholar 

  4. Ong, C.K. et al. Nat. Genet. 44, 690–693 (2012).

    Article  CAS  Google Scholar 

  5. Churi, C.R. et al. PLoS ONE 9, e115383 (2014).

    Article  Google Scholar 

  6. Arai, Y. et al. Hepatology 59, 1427–1434 (2014).

    Article  CAS  Google Scholar 

  7. Nakamura, H. et al. Nat. Genet. 47, 1003–1010 (2015).

    Article  CAS  Google Scholar 

  8. Wu, Y.M. et al. Cancer Discov. 3, 636–647 (2013).

    Article  CAS  Google Scholar 

  9. Borad, M.J. et al. PLoS Genet. 10, e1004135 (2014).

    Article  Google Scholar 

  10. Honeyman, J.N. et al. Science 343, 1010–1014 (2014).

    Article  CAS  Google Scholar 

  11. Nault, J.C. et al. Nat. Commun. 4, 2218 (2013).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Gregory J Gores.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Razumilava, N., Gores, G. Building a staircase to precision medicine for biliary tract cancer. Nat Genet 47, 967–968 (2015).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research