Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Counting copy number and calories

Copy number variation (CNV) at several genomic loci has been associated with different human traits and diseases, but in many cases the findings could not be replicated. A new study provides insights into the degree of variation present at the amylase locus and calls into question a previous association between amylase copy number and body mass index.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Amylase locus variation.

References

  1. Pronk, J.C. et al. Hum. Genet. 60, 32–35 (1982).

    Article  CAS  Google Scholar 

  2. Groot, P.C. et al. Genomics 5, 29–42 (1989).

    Article  CAS  Google Scholar 

  3. Perry, G.H. et al. Nat. Genet. 39, 1256–1260 (2007).

    Article  CAS  Google Scholar 

  4. Falchi, M. et al. Nat. Genet. 46, 492–497 (2014).

    Article  CAS  Google Scholar 

  5. Cantsilieris, S. & White, S.J. Hum. Mutat. 34, 1–13 (2013).

    Article  CAS  Google Scholar 

  6. Cantsilieris, S. et al. BMC Genomics 15, 329 (2014).

    Article  Google Scholar 

  7. Aldhous, M.C. et al. Hum. Mol. Genet. 19, 4930–4938 (2010).

    Article  CAS  Google Scholar 

  8. Usher, C.L. et al. Nat. Genet. 47, 921–925 (2015).

    Article  CAS  Google Scholar 

  9. Handsaker, R.E. et al. Nat. Genet. 43, 269–276 (2011).

    Article  CAS  Google Scholar 

  10. Hindson, B.J. et al. Anal. Chem. 83, 8604–8610 (2011).

    Article  CAS  Google Scholar 

  11. Hastie, A.R. et al. PLoS ONE 8, e55864 (2013).

    Article  CAS  Google Scholar 

  12. Carpenter, D. et al. Hum. Mol. Genet. 24, 3472–3480 (2015).

    Article  CAS  Google Scholar 

  13. Speliotes, E.K. et al. Nat. Genet. 42, 937–948 (2010).

    Article  CAS  Google Scholar 

  14. Chaisson, M.J. et al. Nature 517, 608–611 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Stefan White.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

White, S. Counting copy number and calories. Nat Genet 47, 852–853 (2015). https://doi.org/10.1038/ng.3365

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.3365

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing