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Massive lineage replacements and cryptic outbreaks of Salmonella Typhi in eastern and southern Africa

A new large-scale study reports the whole-genome sequences of nearly 2,000 Salmonella enterica serovar Typhi (S. Typhi) strains collected from 63 countries. A recent and dominant multidrug-resistant (MDR) lineage originating from South Asia, which is supplanting a bulk of ancestral drug-sensitive strains, is identified; the success of this lineage is likely driven by plasmid acquisitions and the chromosomal integration of resistance-conferring genes.

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Figure 1: Indian emigration and standards of living in Africa and Eurasia.


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Correspondence to Thierry Wirth.

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Wirth, T. Massive lineage replacements and cryptic outbreaks of Salmonella Typhi in eastern and southern Africa. Nat Genet 47, 565–567 (2015).

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