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Transposon mutagenesis disentangles osteosarcoma genetic drivers

Nature Genetics volume 47, pages 564565 (2015) | Download Citation

The genetic drivers of osteosarcoma have been difficult to identify because of the genomic complexity consistently encountered in cancer cells at diagnosis. A new study uses Sleeping Beauty transposon mutagenesis to drive osteosarcomagenesis in the mouse and identify likely drivers of the disease in humans.

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Author information

Affiliations

  1. Kevin B. Jones is at the Department of Orthopedics and the Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.

    • Kevin B Jones

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Kevin B Jones.

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DOI

https://doi.org/10.1038/ng.3317

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