The genetic drivers of osteosarcoma have been difficult to identify because of the genomic complexity consistently encountered in cancer cells at diagnosis. A new study uses Sleeping Beauty transposon mutagenesis to drive osteosarcomagenesis in the mouse and identify likely drivers of the disease in humans.
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Jones, K. Transposon mutagenesis disentangles osteosarcoma genetic drivers. Nat Genet 47, 564–565 (2015). https://doi.org/10.1038/ng.3317
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DOI: https://doi.org/10.1038/ng.3317
