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Hypertension linked to PDE3A activation

A new study identifies PDE3A mutations as the cause of brachydactyly type E with hypertension. These mutations alter PDE3A activity by uncovering cryptic sites for phosphorylation by PKA and PKC, leading to enzyme hyperactivation that abnormally lowers cAMP levels.

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Figure 1: HTNB-associated mutations alter PDE3A activity.


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Correspondence to Miles Houslay.

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Houslay, M. Hypertension linked to PDE3A activation. Nat Genet 47, 562–563 (2015).

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