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Hypertension linked to PDE3A activation

Nature Genetics volume 47, pages 562563 (2015) | Download Citation

A new study identifies PDE3A mutations as the cause of brachydactyly type E with hypertension. These mutations alter PDE3A activity by uncovering cryptic sites for phosphorylation by PKA and PKC, leading to enzyme hyperactivation that abnormally lowers cAMP levels.

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Author information

Affiliations

  1. Miles Houslay is at the Institute of Pharmaceutical Science, King's College London, London, UK, and Mironid, Ltd., BioCity Scotland, Newhouse, UK.

    • Miles Houslay

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  1. Search for Miles Houslay in:

Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Miles Houslay.

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DOI

https://doi.org/10.1038/ng.3316

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