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Keeping methylation at bay


A hallmark of CpG islands is their unmethylated state, and determining how DNA methylation can invade these elements is therefore important for understanding developmental gene regulation and disease. A new study shows that FBXL10, a protein commonly altered by mutation in leukemia, is part of a mechanism that blocks methylation of CpG islands.

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Figure 1: FBXL10 is bound at CpG islands as part of the variant PRC1 complex (vPRC1).


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Correspondence to Gavin Kelsey.

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Kelsey, G. Keeping methylation at bay. Nat Genet 47, 427–428 (2015).

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