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Meta-analysis of the heritability of human traits based on fifty years of twin studies

Nature Genetics volume 47, pages 702709 (2015) | Download Citation

Abstract

Despite a century of research on complex traits in humans, the relative importance and specific nature of the influences of genes and environment on human traits remain controversial. We report a meta-analysis of twin correlations and reported variance components for 17,804 traits from 2,748 publications including 14,558,903 partly dependent twin pairs, virtually all published twin studies of complex traits. Estimates of heritability cluster strongly within functional domains, and across all traits the reported heritability is 49%. For a majority (69%) of traits, the observed twin correlations are consistent with a simple and parsimonious model where twin resemblance is solely due to additive genetic variation. The data are inconsistent with substantial influences from shared environment or non-additive genetic variation. This study provides the most comprehensive analysis of the causes of individual differences in human traits thus far and will guide future gene-mapping efforts. All the results can be visualized using the MaTCH webtool.

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Acknowledgements

We would like to thank M. Frantsen, M.P. Roeling, R. Lee and D.M. DeCristo for their contribution to collecting the full texts of selected twin studies and data entry. This work was funded by the Netherlands Organization for Scientific Research (NWO VICI 453-14-005, NWO Complexity 645-000-003), by the Australian Research Council (DP130102666) and by the Australian National Health and Medical Research Council (APP613601).

Author information

Author notes

    • Tinca J C Polderman
    •  & Beben Benyamin

    These authors contributed equally to this work.

    • Peter M Visscher
    •  & Danielle Posthuma

    These authors jointly supervised this work.

Affiliations

  1. Department of Complex Trait Genetics, VU University, Center for Neurogenomics and Cognitive Research, Amsterdam, the Netherlands.

    • Tinca J C Polderman
    • , Christiaan A de Leeuw
    •  & Danielle Posthuma
  2. Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.

    • Beben Benyamin
    •  & Peter M Visscher
  3. Institute for Computing and Information Sciences, Radboud University Nijmegen, Nijmegen, the Netherlands.

    • Christiaan A de Leeuw
  4. Center for Psychiatric Genomics, Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.

    • Patrick F Sullivan
  5. Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA.

    • Patrick F Sullivan
  6. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

    • Patrick F Sullivan
  7. Faculty of Sciences, VU University, Amsterdam, the Netherlands.

    • Arjen van Bochoven
  8. University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia.

    • Peter M Visscher
  9. Department of Clinical Genetics, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands.

    • Danielle Posthuma

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Contributions

D.P., B.B., P.F.S. and P.M.V. performed the analyses. D.P. conceived the study. D.P., T.J.C.P. and P.M.V. designed the study. T.J.C.P. and D.P. collected and entered the data. D.P. and P.F.S. categorized traits according to standard classifications. A.v.B. and C.A.d.L. checked data entries, and checked and wrote statistical scripts. A.v.B. designed and programmed the webtool. D.P., T.J.C.P. and P.M.V. wrote the manuscript. All authors discussed the results and commented on the manuscript.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Danielle Posthuma.

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    Supplementary Text and Figures

    Supplementary Figures 1–12, Supplementary Note and Supplementary Tables 1–19, 22–24 and 26–31.

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    Supplementary Tables 20, 21, 25, 32 and 33.

    Supplementary Tables 20, 21, 25, 32 and 33.

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DOI

https://doi.org/10.1038/ng.3285

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