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Big Bang and context-driven collapse

Heterogeneity is the single most important factor driving cancer progression and treatment failure, yet little is understood about how and when this heterogeneity arises. A new study shows that colorectal cancers acquire their dominant mutations early in development and that subsequent mutations, even if they confer greater fitness, are unlikely to sweep through the tumor.

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Figure 1: Clonal heterogeneity is a product of spatiotemporal evolution.


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Correspondence to Mark Robertson-Tessi or Alexander R A Anderson.

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Robertson-Tessi, M., Anderson, A. Big Bang and context-driven collapse. Nat Genet 47, 196–197 (2015).

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