Supplementary Figure 1 : Comparison of the levels of diversity between coldspots (CS) and highly recombining regions (HRRs) for SNPs in the FCQ data set.

From: Recombination affects accumulation of damaging and disease-associated mutations in human populations

Supplementary Figure 1

Odds ratios (ORs) are computed to compare SNP density between coldspots and HRRs for all SNPs (red) and SNPs divided in different allele frequency classes (black). OR < 1 means that diversity is greater in HRRs than in coldspots. We confirm the lack of diversity in coldspots relative to HRRs, in line with previous evidence that diversity is reduced in regions with low recombination rates owing to background selection. The effect is seen for all frequency classes and does not differ significantly between classes of SNPs with MAF > 0.05. The class of variants with MAF < 0.05 shows a smaller effect than the other frequency classes.