Supplementary Figure 10 : Per-individual differential mutational burden across European populations for private variants.

From: Recombination affects accumulation of damaging and disease-associated mutations in human populations

Supplementary Figure 10

Distribution of odds ratios (ORs) per individual comparing proportions of private variants between coldspots (CS) and highly recombining regions (HRRs) in closely related populations of western European ancestry. ORs are computed on the basis of private variants called in the exome sequencing data set of 96 French Canadians (FCX), 89 British individuals (GBR), 93 Finns (FIN), 98 Italians from Tuscany (TSI) and 85 European Americans (CEU). The left panel shows the frequencies of individual ORs in each population. The right panel shows, for each individual (ordered by their OR values), the relative proportions of private mutations in coldspots and HRRs, computed by dividing coldspot and HRR proportions by genome-wide proportions of private variants within each individual, to adjust for differences across individuals.