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Pseudomonas aeruginosa adaptation to human hosts

Bacterial whole-genome sequencing of longitudinally collected isolates enables the investigation of evolutionary trajectories, which may inform both the prevention and treatment of human-associated pathogen infections. A new study explores the adaptation of multiple lineages of Pseudomonas aeruginosa to the lungs of young patients with cystic fibrosis and finds evidence of convergent molecular evolution and historical contingencies.

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Figure 1: Convergent evolution and historical contingency of P. aeruginosa adaptation to a human host.

Marina Corral Spence/Nature Publishing Group

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Correspondence to Evan S Snitkin or Julia A Segre.

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Snitkin, E., Segre, J. Pseudomonas aeruginosa adaptation to human hosts. Nat Genet 47, 2–3 (2015). https://doi.org/10.1038/ng.3172

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