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Pseudomonas aeruginosa adaptation to human hosts

Nature Genetics volume 47, pages 23 (2015) | Download Citation

Bacterial whole-genome sequencing of longitudinally collected isolates enables the investigation of evolutionary trajectories, which may inform both the prevention and treatment of human-associated pathogen infections. A new study explores the adaptation of multiple lineages of Pseudomonas aeruginosa to the lungs of young patients with cystic fibrosis and finds evidence of convergent molecular evolution and historical contingencies.

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Author information

Affiliations

  1. Julia A. Segre is at the National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.

    • Julia A Segre
  2. Evan S. Snitkin is at the Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

    • Evan S Snitkin

Authors

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Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Evan S Snitkin or Julia A Segre.

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DOI

https://doi.org/10.1038/ng.3172

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