Debette, S. & Leys, D. Cervical-artery dissections: predisposing factors, diagnosis, and outcome. Lancet Neurol. 8, 668–678 (2009).
Rubinstein, S.M., Peerdeman, S.M., van Tulder, M.W., Riphagen, I. & Haldeman, S. A systematic review of the risk factors for cervical artery dissection. Stroke 36, 1575–1580 (2005).
Debette, S. et al. Association of vascular risk factors with cervical artery dissection and ischemic stroke in young adults. Circulation 123, 1537–1544 (2011).
Arnold, M. et al. Vascular risk factors and morphometric data in cervical artery dissection: a case-control study. J. Neurol. Neurosurg. Psychiatry 80, 232–234 (2009).
Debette, S. & Markus, H.S. The genetics of cervical artery dissection: a systematic review. Stroke 40, e459–e466 (2009).
Kathiresan, S. et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat. Genet. 41, 334–341 (2009).
Deloukas, P. et al. Large-scale association analysis identifies new risk loci for coronary artery disease. Nat. Genet. 45, 25–33 (2013).
Freilinger, T. et al. Genome-wide association analysis identifies susceptibility loci for migraine without aura. Nat. Genet. 44, 777–782 (2012).
Anttila, V. et al. Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nat. Genet. 45, 912–917 (2013).
Debette, S. et al. Differential features of carotid and vertebral artery dissections: the CADISP study. Neurology 77, 1174–1181 (2011).
Debette, S. et al. CADISP-genetics: an international project searching for genetic risk factors of cervical artery dissections. Int. J. Stroke 4, 224–230 (2009).
Wakefield, J. Bayes factors for genome-wide association studies: comparison with P-values. Genet. Epidemiol. 33, 79–86 (2009).
Pezzini, A. et al. Plasma homocysteine concentration, C677T MTHFR genotype, and 844ins68bp CBS genotype in young adults with spontaneous cervical artery dissection and atherothrombotic stroke. Stroke 33, 664–669 (2002).
Pezzini, A. et al. Migraine mediates the influence of C677T MTHFR genotypes on ischemic stroke risk with a stroke-subtype effect. Stroke 38, 3145–3151 (2007).
Longoni, M. et al. The ICAM-1 E469K gene polymorphism is a risk factor for spontaneous cervical artery dissection. Neurology 66, 1273–1275 (2006).
Pepin, M., Schwarze, U., Superti-Furga, A. & Byers, P.H. Clinical and genetic features of Ehlers-Danlos syndrome type IV, the vascular type. N. Engl. J. Med. 342, 673–680 (2000).
Low, S.K. et al. Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA. Hum. Mol. Genet. 21, 2102–2110 (2012).
Bilguvar, K. et al. Susceptibility loci for intracranial aneurysm in European and Japanese populations. Nat. Genet. 40, 1472–1477 (2008).
Yasuno, K. et al. Genome-wide association study of intracranial aneurysm identifies three new risk loci. Nat. Genet. 42, 420–425 (2010).
Lemaire, S.A. et al. Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1. Nat. Genet. 43, 996–1000 (2011).
O'Donnell, C.J. et al. Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction. Circulation 124, 2855–2864 (2011).
Lu, X. et al. Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. Nat. Genet. 44, 890–894 (2012).
Hager, J. et al. Genome-wide association study in a Lebanese cohort confirms PHACTR1 as a major determinant of coronary artery stenosis. PLoS ONE 7, e38663 (2012).
Mehta, N.N. A genome-wide association study in Europeans and South Asians identifies 5 new loci for coronary artery disease. Circ. Cardiovasc. Genet. 4, 465–466 (2011).
Schunkert, H. et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat. Genet. 43, 333–338 (2011).
Coronary Artery Disease (C4D) Genetics Consortium. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat. Genet. 43, 339–344 (2011).
Bevan, S. et al. Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations. Stroke 43, 3161–3167 (2012).
Bellenguez, C. et al. Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nat. Genet. 44, 328–333 (2012).
Traylor, M. et al. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol. 11, 951–962 (2012).
Smyth, D.J. et al. Shared and distinct genetic variants in type 1 diabetes and celiac disease. N. Engl. J. Med. 359, 2767–2777 (2008).
Calvet, D. et al. Increased stiffness of the carotid wall material in patients with spontaneous cervical artery dissection. Stroke 35, 2078–2082 (2004).
Golledge, J. & Eagle, K.A. Acute aortic dissection. Lancet 372, 55–66 (2008).
Norman, P.E., Davis, T.M., Le, M.T. & Golledge, J. Matrix biology of abdominal aortic aneurysms in diabetes: mechanisms underlying the negative association. Connect. Tissue Res. 48, 125–131 (2007).
Shantikumar, S., Ajjan, R., Porter, K.E. & Scott, D.J. Diabetes and the abdominal aortic aneurysm. Eur. J. Vasc. Endovasc. Surg. 39, 200–207 (2010).
Callaghan, F.M. et al. Wall stress of the cervical carotid artery in patients with carotid dissection: a case-control study. Am. J. Physiol. Heart Circ. Physiol. 300, H1451–H1458 (2011).
Kurth, T. et al. Headache, migraine, and structural brain lesions and function: population based Epidemiology of Vascular Ageing-MRI study. Br. Med. J. 342, c7357 (2011).
Chasman, D.I. et al. Genome-wide association study reveals three susceptibility loci for common migraine in the general population. Nat. Genet. 43, 695–698 (2011).
Metso, T.M. et al. Migraine in cervical artery dissection and ischemic stroke patients. Neurology 78, 1221–1228 (2012).
Allen, P.B., Greenfield, A.T., Svenningsson, P., Haspeslagh, D.C. & Greengard, P. Phactrs 1–4: a family of protein phosphatase 1 and actin regulatory proteins. Proc. Natl. Acad. Sci. USA 101, 7187–7192 (2004).
Allain, B. et al. Neuropilin-1 regulates a new VEGF-induced gene, Phactr-1, which controls tubulogenesis and modulates lamellipodial dynamics in human endothelial cells. Cell. Signal. 24, 214–223 (2012).
Jarray, R. et al. Depletion of the novel protein PHACTR-1 from human endothelial cells abolishes tube formation and induces cell death receptor apoptosis. Biochimie 93, 1668–1675 (2011).
Fils-Aimé, N. et al. MicroRNA-584 and the protein phosphatase and actin regulator 1 (PHACTR1), a new signaling route through which transforming growth factor-β mediates the migration and actin dynamics of breast cancer cells. J. Biol. Chem. 288, 11807–11823 (2013).
Goumans, M.J., Liu, Z. & ten Dijke, P. TGF-β signaling in vascular biology and dysfunction. Cell Res. 19, 116–127 (2009).
Loeys, B.L. et al. A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Nat. Genet. 37, 275–281 (2005).
Zhang, X. et al. Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes. Hum. Mol. Genet. 23, 782–795 (2014).
Westra, H.J. et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat. Genet. 45, 1238–1243 (2013).
Bown, M.J. et al. Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor–related protein 1. Am. J. Hum. Genet. 89, 619–627 (2011).
Lee, V.H., Brown, R.D. Jr., Mandrekar, J.N. & Mokri, B. Incidence and outcome of cervical artery dissection: a population-based study. Neurology 67, 1809–1812 (2006).
Pruim, R.J. et al. LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics 26, 2336–2337 (2010).
Price, A.L. et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38, 904–909 (2006).
Thomas, D. Gene—environment-wide association studies: emerging approaches. Nat. Rev. Genet. 11, 259–272 (2010).