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PRC2 loss amplifies Ras signaling in cancer

The histone-modifying PRC2 complex has an ambiguous role in cancer, bearing both oncogenic and tumor-suppressive features depending on cell type. Studies of malignant peripheral nerve sheath tumors (MPNSTs) have now identified loss-of-function mutations altering PRC2 subunits, leading to the amplification of Ras-driven transcription and conferring vulnerability to BRD4 inhibitors.

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Figure 1: PRC2 loss cooperates with Ras activation to drive tumor progression in MPNSTs.

Katie Vicari/Nature Publishing Group

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Correspondence to Christoph Plass.

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Baude, A., Lindroth, A. & Plass, C. PRC2 loss amplifies Ras signaling in cancer. Nat Genet 46, 1154–1155 (2014). https://doi.org/10.1038/ng.3124

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