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Tetrad analysis in the mouse

Meiotic tetrad analysis is a powerful tool for analyzing all four products of a single meiosis. A new method for tetrad analysis in mammals provides valuable insights into the mechanisms that mediate the exchange of DNA sequences between homologs during meiosis and their influence on the evolution of recombination hotspots.

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Figure 1: Tetrad analysis allows the recovery of all four products of a single meiosis.


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Correspondence to R Scott Hawley.

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Miller, D., Hawley, R. Tetrad analysis in the mouse. Nat Genet 46, 1045–1046 (2014).

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