A new study describes a tool, Lentihop, for somatic insertional mutagenesis in human cells and uses this system in combination with cancer genome data to define new genes and pathways involved in sarcoma development. Gene discovery in this way suggests that we are far from a complete catalog of cancer drivers.
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van der Weyden, L., Ranzani, M. & Adams, D. Cancer gene discovery goes mobile. Nat Genet 46, 928–929 (2014). https://doi.org/10.1038/ng.3072
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DOI: https://doi.org/10.1038/ng.3072
