Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

From genomics to diagnostics of esophageal adenocarcinoma

The genetic determinants of progression from premalignant Barrett's esophagus to esophageal adenocarcinoma are not known. A new study reports genomic sequence analyses of this progression and uses the insights gained to identify high-risk Barrett's esophagus in a new non-endoscopic test.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Potential role for the Cytosponge in clinical care.

Debbie Maizels/Nature Publishing Group

References

  1. Ferlay, J. et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide, http://globocan.iarc.fr/ (2013).

  2. Kroep, S. et al. Am. J. Gastroenterol. 109, 336–343 (2014).

    Article  CAS  PubMed  Google Scholar 

  3. Vogelstein, B. et al. Science 339, 1546–1558 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Weaver, J.M.J. et al. Nat. Genet. 46, 837–843 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Reid, B.J., Li, X., Galipeau, P.C. & Vaughan, T.L. Nat. Rev. Cancer 10, 87–101 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Wang, K.K. & Sampliner, R.E. Am. J. Gastroenterol. 103, 788–797 (2008).

    Article  PubMed  Google Scholar 

  7. Li, X. et al. Cancer Prev. Res. (Phila.) 7, 114–127 (2014).

    Article  Google Scholar 

  8. Corley, D.A. et al. Gastroenterology 145, 312–319 (2013).

    Article  PubMed  Google Scholar 

  9. Gordon, L.G. et al. Gastrointest. Endosc. 79, 242–256 (2014).

    Article  PubMed  Google Scholar 

  10. Dulak, A.M. et al. Nat. Genet. 45, 478–486 (2013).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Agrawal, N. et al. Cancer Discov. 2, 899–905 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Galipeau, P.C. et al. PLoS Med. 4, e67 (2007).

    Article  PubMed  PubMed Central  Google Scholar 

  13. Kadri, S.R. et al. Br. Med. J. 341, c4372 (2010).

    Article  Google Scholar 

  14. Kong, C.Y. et al. Cancer Epidemiol. Biomarkers Prev. 23, 997–1006 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Thomas L Vaughan.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vaughan, T. From genomics to diagnostics of esophageal adenocarcinoma. Nat Genet 46, 806–807 (2014). https://doi.org/10.1038/ng.3047

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.3047

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing